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[3H]L-657, 743 (MK-912): A new, high affinity, selective radioligand for brain α2-adrenoceptors

✍ Scribed by D.J. Pettibone; S.D. Flagg; J.A. Totarol; B.V. Clineschmidt; J.R. Huff; S.D. Young; R. Chen

Book ID: 118343871
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 445 KB
Volume: 44
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(89)90461-x

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## Abstract [^3^H]TCP, an analog of the dissociative anesthetic phencyclidine (PCP), binds with high affinity to two sites in guinea pig brain membranes, one that is MK‐801 sensitive and one that is not. The MK‐801‐sensitive site (PCP site 1) is associated with NMDA receptors, whereas the MK‐801‐in