[3H]Imipramine binding in type I and type II alcoholism

✍ Scribed by A. A. Patkar; P. C. Naik; C. A. Mardsen; P. C. McKlean; D. A. Kendall; T. Al-Chalabi

• Book ID: 102261933
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 479 KB
• Volume: 10
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470100410

✦ Synopsis

Abstract

Platelet [^3^H]‐imipramine binding was measured in 29 male alcohol dependents (DSM III‐R) serially over 14 days of withdrawal. 29 male abstainers and 20 healthy volunteers. [^3^H]‐Imipramine binding was significantly greater in alcohol dependents and abstainers when compared with controls. On further grouping, type II alcoholism was specifically associated with the raised imipramine binding and this occurred irrespective of the duration or severity of drinking or the length of abstinence. The result indicates that platelet [^3^H]‐imipramine binding could be a biological marker of type II alcoholism.