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[3H]Haloperidol binding to more than one site in rat brain striatum

✍ Scribed by Daiga M. Helmeste; Philip Seeman


Book ID
115777135
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
395 KB
Volume
32
Category
Article
ISSN
0006-2952

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Methyl mercury inhibits dopamine (DA) and serotonin (5-HT) uptake by brain synaptosomes and decreases antagonist binding to striatal dopaminergic D2 receptors in vitro. To assess the effects in vivo, adult rats were given methyl mercury, either as a single dose (10 mg/kg by gavage) or a cumulative t