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[3H]GBR 12935 binding in platelets: A possible association with cytochrome P-450IID6?

✍ Scribed by Maria Norlén; Per Allard


Book ID
119413953
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
155 KB
Volume
332
Category
Article
ISSN
0014-2999

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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab