[3H]d-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study
โ Scribed by Pamela J. Shaw; Rachel M. Chinnery; Paul G. Ince
- Book ID
- 115805173
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 837 KB
- Volume
- 655
- Category
- Article
- ISSN
- 0006-8993
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In the present work the distribution of L-glutamate binding sites in the different layers of human cerebellum of normal individuals and of seven patients who died with olivopontocerebellar atrophy (OPCA) was examined with the technique of quantitative autoradiography. Specific L-[3H]glutamate bindin
Using quantitative autoradiography, we have characterized the binding properties of the non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist ["H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in adult human cerebellum. Saturation experiments revealed [3H]CNQX binding to a single class of sites