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[3H]cocaine binding and inhibition of [3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens

โœ Scribed by John W. Boja; Michael J. Kuhar


Book ID
115882553
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
221 KB
Volume
173
Category
Article
ISSN
0014-2999

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Methyl mercury inhibits dopamine (DA) and serotonin (5-HT) uptake by brain synaptosomes and decreases antagonist binding to striatal dopaminergic D2 receptors in vitro. To assess the effects in vivo, adult rats were given methyl mercury, either as a single dose (10 mg/kg by gavage) or a cumulative t