A series of 2-1(substituted)phenyl]-5-[1-(2-phenylazacycloheptyl)methyl]-lH-pyrroles (8 -15) has been prepared to investigate the effect on affinity and selectivity for the dopamine D 3 receptor of modifying the substituent in the phenyl ring at the 2-position of the pyrrole. Sulfonate 7 and sulfona
โฆ LIBER โฆ
[3H]205-501, a Non-catechol dopaminergic agonist, labels selectively and with high affinity dopamine D2receptors
โ Scribed by Annemarie Closse; W. Frick; R. Markstein; R. Maurer; R. Nordmann
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 833 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1435-1463
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## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptorโselective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^โacylโimidazolylpropylguanidine with 2โaminothiazole yielded potent and selective H~2~ recepto