3D radial projection technique with ultrashort echo times for sodium MRI: Clinical applications in human brain and skeletal muscle
✍ Scribed by Sònia Nielles-Vallespin; Marc-André Weber; Michael Bock; André Bongers; Peter Speier; Stephanie E. Combs; Johannes Wöhrle; Frank Lehmann-Horn; Marco Essig; Lothar R. Schad
- Book ID
- 102532826
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 489 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
^23^Na MRI has the potential to noninvasively detect sodium (Na) content changes in vivo. The goal of this study was to implement ^23^Na MRI in a clinical setting for neurooncological and muscular imaging. Due to the biexponential T~2~ decay of the tissue Na signal with a short component, which ranges between 0.5–8 ms, the measurement of total Na content requires imaging techniques with echo times (TEs) below 0.5 ms. A 3D radial pulse sequence with a TE of 0.2 ms at a spatial resolution of 4 × 4 × 4 mm^3^ was developed that allows the acquisition and presentation of Na images on the scanner. This sequence was evaluated in patients with low‐ and high‐grade gliomas, and higher ^23^Na MR signals corresponding to an increased Na content were found in the tumor regions. The contrast‐to‐noise ratio (CNR) between tumor and white matter increased from 0.8 ± 0.2 to 1.3 ± 0.3 with tumor grade. In patients with an identified muscular ^23^Na channelopathy (Paramyotonia congenita (PC)), induced muscle weakness led to a signal increase of ∼18% in the ^23^Na MR images, which was attributed to intracellular Na^+^ accumulation in this region. Magn Reson Med 57:74–81, 2007. © 2006 Wiley‐Liss, Inc.