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3D QSAR studies on peroxisome proliferator-activated receptor γ agonists using CoMFA and CoMSIA

✍ Scribed by Chenzhong Liao; Aihua Xie; Jiaju Zhou; Leming Shi; Zhibin Li; Xian-Ping Lu


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
572 KB
Volume
10
Category
Article
ISSN
1610-2940

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## Abstract Peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) plays a critical role in glucose and lipid metabolism. More recently, PPAR‐γ ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR‐γ agoni