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3D QSAR STUDIES OF INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR [EGFR] USING CoMFA AND GFA METHODOLOGIES

โœ Scribed by Deepa V. Pednekar; Mandar A. Kelkar; Surekha R. Pimple; Krishnacharya G. Akamanchi


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
734 KB
Volume
13
Category
Article
ISSN
1054-2523

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โœ Nicola Normanno; Monica R. Maiello; Antonella De Luca ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 157 KB

## Abstract A range of targetโ€based agents for the treatment of solid tumors are in development. The epidermal growth factor receptor (EGFR) has been identified as a relevant target as it is involved in regulating several cellular functions important in the proliferation and survival of cancer cell