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3D-QSAR and Receptor Modeling of Tyrosine Kinase Inhibitors with Flexible Atom Receptor Model (FLARM).

✍ Scribed by Tao Peng; Jianfeng Pei; Jiaju Zhou


Publisher
John Wiley and Sons
Year
2003
Weight
53 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new