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399 DEVELOPMENT AND CHARACTERIZATION OF CLINICALLY RELEVANT TUMOR MODELS FROM PATIENTS WITH RENAL CELL CARCINOMA

✍ Scribed by Karam, Jose; Zhang, Xiu-Ying; Tamboli, Pheroze; Margulis, Vitaly; Wang, Hua; Abel, E. Jason; Culp, Stephen; Wood, Christopher


Book ID
122605603
Publisher
Lippincott Williams and Wilkins
Year
2011
Tongue
English
Weight
107 KB
Volume
185
Category
Article
ISSN
0022-5347

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## BACKGROUND. Urokinase plasminogen activator (u-PA) plays a key role in the metastatic process by promoting plasmin mediated tissue degradation. Metastatic cell invasion requires localized proteolysis, which may be directed by u-PA receptor. The binding of u-PA and PAI-1 to the u-PA-receptor may