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397 POSTER Potentiation of the antitumor activity of bortezomib, a proteasome inhibitor, by the combination with EGFR inhibitors in human cancer cell lines

✍ Scribed by T. Cascone; F. Morgillo; G. Laus; S. Pepe; F. Ciardiello

Book ID: 118624025
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 56 KB
Volume: 4
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(06)70402-5

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## Abstract The proteasome plays a pivotal role in the turnover of regulatory transduction proteins induced by activated cell membrane growth factor receptors. The epidermal growth factor receptor (EGFR) pathway is crucial in the development and progression of human epithelial cancers. Proteasome i