[395] MUTATIONS IN THE PRECORE REGION OF ASIAN HEPATITIS B VIRUS GENOTYPE C AFFECTING HEPATITIS B e ANTIGEN PRODUCTION
โ Scribed by S.H. Ahn; H.Y. Chang; M.E. Lee; K.H. Kim; Y.H. Paik; K.S. Lee; K.H. Han; C.Y. Chon; Y.M. Moon
- Book ID
- 117375490
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 143 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0168-8278
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Mutations in the core promoter and precore regions are frequently found in hepatitis B e antigen (HBeAg)-negative patients, but precore stop codon mutation is restricted to hepatitis B virus (HBV) genotypes that have T at nucleotide 1858. The aims of this study were to determine the role of core pro
We previously reported two mutually exclusive mutations in the precore region of hepatitis B virus: MI (T-1856, proline-serine substitution at codon 15) and M 2 (A-1896, stop codon at codon 28). This study was conducted to determine if the presence of precore mutants affect spontaneous or interferon
To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted