392 Urokinase plasminogen activator (u-PA) in serous ovarian tumors. Translocation of mRNA expression from the epithelium in benign and well differentiated to the stroma in poorly differentiated tumors

High tissue content of urokinase plasmin

High tissue content of urokinase plasminogen activator (u-PA) is associated with high stromal expression of u-PA mRNA in poorly differentiated serous ovarian carcinoma

✍ Christer Borgfeldt; Bertil Casslén; Chun-Li Liu; Stefan Hansson; Ingegerd Lecand 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 842 KB

Urokinase plasminogen activator (u-PA) plays a pivotal role in tissue degradation during tumor spread and metastasis. We have quantitated u-PA in tissue homogenates of 31 serous ovarian tumors and localized u-PA and its mRNA in tissue sections of 26 serous ovarian tumors. The content of u-PA was hig