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390 Enhanced suppression of Raf-1 activity by K vitamins mediates their synergy with Sorafenib to inhibit HCC cell growth in vitro and in vivo

โœ Scribed by B. Carr; Z. Wang; M. Wang

Book ID
119602171
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
45 KB
Volume
8
Category
Article
ISSN
1359-6349

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โœ Gang Wei; Meifang Wang; Terry Hyslop; Ziqiu Wang; Brian I. Carr ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 775 KB

## Abstract The multikinase inhibitor sorafenib is the first oral agent to show activity against human hepatocellular carcinoma (HCC). Apoptosis has been shown to be induced in HCC by several agents, including sorafenib as well as by the naturally occurring K vitamins (VKs). As few nontoxic agents