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386 MCL-1 as a novel target for antisense therapy of hepatocellular carcinoma

Book ID
117373897
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
134 KB
Volume
42
Category
Article
ISSN
0168-8278

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Human carbonyl reductase 1 (CBR1) converts the antitumor drug and anthracycline daunorubicin (DNR) into the alcohol metabolite daunorubicinol (DNROL) with significantly reduced antitumor activity and cardiotoxicity, and this limits the clinical use of DNR. Inhibition of CBR1 can thus increase the ef