379 - Improving tumour targeting and decreasing normal tissue uptake by optimizing stoichiometry of a two-step biotinylated monoclonal antibody (Mab)/streptavldin (Strv) based targeting strategy: Studies in a nude mouse xenograft model

Improving tumour targeting and decreasin

Improving tumour targeting and decreasing normal tissue uptake by optimizing the stoichiometry of a two-step biotinylated-antibody/streptavidin-based targeting strategy: Studies in a nude mouse xenograft model

✍ Anthony Maraveyas; Gail Rowlinson-Busza; Samuel Murray; Agamemnon A. Epenetos 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 114 KB 👁 2 views

We aimed to study in detail the in vivo stoichiometry of the individual elements of the 2-step streptavidin based approach to tumour targeting, in a nude mouse xenograft model, by the administration of a first step consisting of biotinylated anti-tumour specific antibody and a second step consisting