376 - Employment of the mdr1 promoter for a conditionally active retroviral vector system in cancer gene therapy
โ Scribed by W. Walther; U. Stein; J. Wendt; R.H. Shoemaker
- Book ID
- 117664631
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 264 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
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## Abstract ## Background The use of retroviral vectors has shown an actual clinical benefit in a few inherited diseases. However, the occurrence of cases of leukemia after the XโSCID gene therapy trial raised concerns about the safety of insertional mutagenesis inherent to the biology of the retr
Cellular multi-drug resistance (MDR), which often develops in cancer cells of patients subjected to anti-cancer treatment, remains a significant barrier to successful cancer therapy. One of the principal causes of cellular MDR development is an increased expression of ABC-transporter genes such as m