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36 Transcriptional signature associated with sensitivity to ET-743 (Yondelis) in low passage sarcoma cell lines

✍ Scribed by M. Sanchez Beato; N. Martinez; I. Fernandez; M. Navarrete; P. de la Cueva; A. Carnero; J.C. Tercero; J. Jimeno; M.A. Piris

Book ID
118621221
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
136 KB
Volume
2
Category
Article
ISSN
1359-6349

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Extreme sensitivity to Yondelis® (Trabec
Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53
✍ Victoria Moneo; Beatriz G. Serelde; Jesús Fominaya; Juan F.M. Leal; Carmen Blanc 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

## Abstract Yondelis® (Trabectedin, ET‐743) is a marine anticancer agent currently in Phase II/III development in patients with advanced pretreated soft tissue sarcoma. In the present study, we generated a panel of low passaged tumor cell lines from samples explanted from chemonaive sarcoma patient