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356 SECRETED FRIZZLED-RELATED PROTEIN-5 (SFRP-5) IS EPIGENETICALLY DOWNREGULATED AND FUNCTIONS AS A TUMOR SUPPRESSOR IN RENAL CELL CANCER

✍ Scribed by Kawakami, Kazumori; Yamamura, Soichiro; Hirata, Hiroshi; Ueno, Koji; Saini, Sharanjot; Majid, Shahana; Tanaka, Yuichiro; Kawamoto, Ken; Enokida, Hideki; Nakagawa, Masayuki; Dahiya, Rajvir

Book ID: 121986732
Publisher: Lippincott Williams and Wilkins
Year: 2010
Tongue: English
Weight: 42 KB
Volume: 183
Category: Article
ISSN: 0022-5347
DOI: 10.1016/j.juro.2010.02.423

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Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer

✍ Kazumori Kawakami; Soichiro Yamamura; Hiroshi Hirata; Koji Ueno; Sharanjot Saini 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 592 KB

## Abstract Secreted frizzled‐related protein‐5 (__sFRP‐5__) has been identified as 1 of the secreted antagonists that bind Wnt protein. However, the functional significance of __sFRP‐5__ in renal cell cancer (RCC) has not been reported. We hypothesized that __sFRP‐5__ may be epigenetically downreg