350 SPONTANEOUS AND PERSISTENT ACTIVATION OF PPAR ALPHA IN HCV CORE PROTEIN TRANSGENIC MICE: IMPLICATIONS FOR HCV-ASSOCIATED HEPATOCARCINOGENESIS

Hepatitis C virus core protein induces s

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor α in transgenic mice: Implications for HCV-associated hepatocarcinogenesis

✍ Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Toshifumi Aoyama 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 493 KB

## Abstract Persistent infection of hepatitis C virus (HCV) can lead to a high risk for hepatocellular carcinoma (HCC). HCV core protein plays important roles in HCV‐related hepatocarcinogenesis, because mice carrying the core protein exhibit multicentric HCCs without hepatic inflammation and fibro