3,5-Di-p-toluoyl-1,2-dideoxy-β-1-(imidazol-1-yl)-d-ribofuranose

✍ Scribed by Düpre, Nicole ;Shen, Wei-Zheng ;Sanz Miguel, Pablo J. ;Müller, Jens

• Book ID: 104492445
• Publisher: International Union of Crystallography
• Year: 2007
• Tongue: English
• Weight: 755 KB
• Volume: 63
• Category: Article
• ISSN: 1600-5368
• DOI: 10.1107/s1600536807056760

✦ Synopsis

The title compound, C 24 H 24 N 2 O 5 , was obtained as a reaction intermediate in the synthesis of the artificial imidazole nucleoside, which is a highly useful synthetic nucleoside for the formation of metal-ion-mediated base pairs. Compared to the free nucleoside, both OH groups of the sugar moiety are protected by p-toluoyl groups. The sugar is in its C3 0 -endo conformation.

Related literature

The structures of the analogous 1,2,4-triazole and tetrazole nucleosides have been reported recently (Mu ¨ller et al., 2005). These nucleosides have been used in metal-ion-mediated base pairs (Bo ¨hme et al., 2007