344. Influence of tryptophan depletion on mood and immune measures in healthy males
โ Scribed by A.V. Ravindran; J. Griffiths; Z. Merali; V.J. Knott; H. Anisman
- Book ID
- 118513055
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 247 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0006-3223
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We studied 12 healthy subjects, six males and six females, using the technique of tryptophan depletion in a doubleblind placebo controlled crossover design. Subjects rated their subjective mood and also underwent a mood induction procedure. The tryptophan free mixture signiยฎcantly lowered plasma tot
In a previous study we found that a tryptophan-deficient amino acid mixture, designed to lower tissue tryptophan and thus brain 5-hydroxytryptamine (5HT) levels, caused a rapid (5 h) lowering of mood in normal males. Because of the importance of this evidence indicating a direct causal connection be