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330 POSTER Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents against non-small cell lung cancer (NSCLC)

✍ Scribed by S. Sei; Q. Yang; J. Mussio; M. Coffey; R. Parchment; R. Shoemaker; J. Tomaszewski


Book ID
118623958
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
61 KB
Volume
4
Category
Article
ISSN
1359-6349

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## Abstract The combination therapy of CPT‐11, a prodrug of SN‐38, with S‐1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, shows a high clinical response rate in non‐small cell lung cancer (NSCLC). However, this combination causes severe toxicities such as diarrhea. Here, we invest