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32P-postlabeling detection of DNA adducts in mice treated with the herbicide roundup

✍ Scribed by Marco Peluso; Armelle Munnia; Claudia Bolognesi; Silvio Parodi

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
129 KB
Volume
31
Category
Article
ISSN
0893-6692

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✦ Synopsis

Roundup is a postemergence herbicide acting on 1.7 { 0.1 (SE) adducts/10 8 nucleotides, respecthe synthesis of amino acids and other important tively. The Roundup DNA adducts were not related endogenous chemicals in plants. Roundup is com-to the active ingredient, the isopropylammonium monly used in agriculture, forestry, and nurseries salt of glyphosate, but to another, unknown compofor the control or destruction of most herbaceous nent of the herbicide mixture. Additional experiplants. The present study shows that Roundup is ments are needed to identify the chemical specie(s) able to induce a dose-dependent formation of DNA of Roundup mixture involved in DNA adduct formaadducts in the kidneys and liver of mice. The levels tion. Findings of this study may help to protect agof Roundup-related DNA adducts observed in ricultural workers from health hazards and provide mouse kidneys and liver at the highest dose of herbi-a basis for risk assessment. Environ. Mol. Mutagen. cide tested (600 mg/kg) were 3.0

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