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329 Antitumor activity in preclinical xenograft models of OSI-930, a novel selective tyrosine kinase inhibitor

✍ Scribed by S.L. Winski; M.A. Bittner; P. Briner; E.N. Brown; A.R. Cooke; A. Crew; C. Hidden; C. Pirrit; M.S. Srebernak; D.L. Emerson


Book ID
118621511
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
154 KB
Volume
2
Category
Article
ISSN
1359-6349

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## Abstract E7080 is an inhibitor of multiple tyrosine kinases, several of which have pro‐angiogenic properties, including receptors for VEGF, FGF, SCF and PDGF. We undertook our study to evaluate the preclinical activity of E7080 in human sarcomas. The antitumour activity of orally administered E7