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327 PHARMACOLOGICAL INHIBITION OF JAK/STAT SIGNALING PREVENTS HIGH-GLUCOSE-INDUCED UP-REGULATION OF ENDOTHELIN-1 EXPRESSION IN HUMAN ENDOTHELIAL CELLS

✍ Scribed by Manea, S.; Manea, A.; Heltianu, C.

Book ID: 118639334
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 57 KB
Volume: 12
Category: Article
ISSN: 1567-5688
DOI: 10.1016/s1567-5688(11)70328-2

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## Abstract Hyperglycemia is the hallmark of diabetes mellitus. Poor glycemic control is correlated with increased cardiovascular morbidity and mortality. High glucose can trigger endothelial cell apoptosis by de‐activation of endothelial nitric oxide synthase (eNOS). eNOS was recently demonstrated