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326 Stimulation of interstitial collagenase activity by halofuginone in hepatic stellate cells is dependent on activation of P38 and NF kappa B

✍ Scribed by Y. Popov; E. Patsenker; E. Niedobitek; M. Bauer; M. Pines; D. Schuppan

Book ID: 117373156
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 57 KB
Volume: 40
Category: Article
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(04)90326-1

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in