31Phosphorus nuclear magnetic resonance spectroscopy: What does it tell us about alcohol-induced liver disease?
✍ Scribed by R. A. Willson
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 393 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
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Patients with a history of alcohol abuse were studied by "P n.m.r. spectroscopy of the liver in uiuo, and the results were related to the pattern of disease assessed by standard biochemical and histological techniques.
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The ratios of metabolites measured from the "'P n.m.r. epectra were abnormal in patients with alcoholic hepatitis but not in those with fatty change or cirrhosis in the absence of hepatitis. In particular, the levels of phosphomonoesters were raised, with respect either to Pi, or to adenosine 6'-triphosphate. The level of phosphomonoesters showed a significant positive correlation with the severity of alcoholic hepatitis, assessed by histology.
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The ratio of Pi to adenosine 5'4riphosphate was used as a measure of the energy status of the hepatocytes, and was unchanged between patients and controls.