31P Solid-State NMR study of the chemical setting process of a dual-paste injectable brushite cements

✍ Scribed by A. P. Legrand; H. Sfihi; N. Lequeux; J. Lemaître

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 490 KB
• Volume: 91B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31372

✦ Synopsis

Abstract

The composition and evolution of a brushite‐type calcium phosphate cement was investigated by Solid‐State NMR and X‐ray during the setting process. The cement is obtained by mixing β‐tricalcium phosphate [Ca~3~(PO~4~)~2~, β‐TCP] and monocalcium phosphate monohydrate [Ca(H~2~PO~4~)~2~.H~2~O, MCPM] in presence of water, with formation of dicalcium phosphate dihydrate or brushite [CaHPO~2~·2H~2~O, DCPD]. Analysis of the initial β‐TCP paste has shown the presence of β‐calcium pyrophosphate [Ca~2~P~2~O~7~, β‐CPy] and that of the initial MCPM a mixture of MCPM and dicalcium phosphate [CaHPO~4~, DCP]. Follow‐up of the chemical composition by ^31^P Solid‐State NMR enables to show that the chemical setting process appeared to reach an end after 20 min. The constant composition observed at the end of the process was similarly determined. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009