31P NMR studies on the interaction of morpholinyl anthracyclines and related compounds with d(CGTACG)2. Thermodynamic and kinetic parameters

Studies on the structure of the complex

Studies on the structure of the complex of the boron neutron capture therapy drug, L-p-boronophenylalanine, with fructose and related carbohydrates: Chemical and 13C NMR evidence for the β-D-fructofuranose 2,3,6-(p-phenylalanylorthoboronate) structure

✍ Brian K. Shull; David E. Spielvogel; Gerald Head; Ramesh Gopalaswamy; Sabapathy 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB 👁 2 views

The complex of L-p-boronophenylalanine (L-p-BPA) with fructose has been used for the past 5 years in clinical trials of boron neutron capture therapy to treat both melanoma and glioblastoma multiforme. However, the structure of this complex in water buffered at physiologic pH has not been establishe