## Abstract To determine whether direct cellular effects of chemotherapy are responsible for ^31^P NMR spectral changes observed in treated tumors __in vivo__, RIF‐1 fibrosarcoma cells were examined __in vitro__ before, during, and after treatment with 4‐hy‐droperoxycyclophosphamide (4‐HC), an acti
31P NMR spectroscopic and near infrared spectrophotometric studies of effects of anesthetics on In vivo RIF-1 tumors. relationship to tumor radiosensitivity
✍ Scribed by R. Grant Steen; David A. Wilson; Cindy Bowser; Janna P. Wehrle; Jerry D. Glickson; S. Sunder Rajan
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 717 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0952-3480
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## Abstract In order to examine the mechanisms underlying radiation‐induced changes in phosphorus metabolite levels observed in RIF‐1 tumors __in vivo__, RIF‐1 cells in culture were perfused for up to 70 h following γ‐irradiation with 0‐25 Gy and monitored continuously by, ^31^P NMR spectroscopy at
The principal aim of these studies was to evaluate the utility of isoflurane and halothane for NMR investigations of tumor physiology. In vivo 31P and 2H NMR were used to examine RIF-1 tumors before, during, and (for 31P) after anesthesia. In tumors, halothane decreases blood flow, [PCR]:[NTP], and