31P changes as a measure of therapy response in human osteosarcomas implanted into nude mice

✍ Scribed by H. Kang; J.R. Ballinger; C. Sweeney; B.P. Croker; K.N. Scott

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 977 KB
• Volume: 12
• Category: Article
• ISSN: 0730-725X
• DOI: 10.1016/0730-725x(94)92034-6

✦ Synopsis

Our objective was to determine whether changes in PME and PCr/Pi can be used to predict lack of tumor response to chemotherapy in a murine model of human osteosarcoma. Cisplatin sensitive and resistant human osteosarcoma cell lines were implanted into a total of 22 nude mice. 3*P MR spectroscopy was performed pre-and post chemotherapy in both sets of mice. Statistically significant changes in PCr/Pi occur as a result of chemotherapy prior to changes in tumor volume in sensitive tumors. Changes in PME parallel changes in tumor volume. No significant changes were seen in resistant tumors. Changes in PCr/Pi predict lack of tumor treatment response in human osteosarcoma implanted into nude mice with a specificity of 80% and a sensitivity of 63%.