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318. Polymerisation of flavans. Part VI. Reduction of flavanoids and chalcones with lithium aluminium hydride in the presence of aluminium chloride

✍ Scribed by Bokadia, M. M. ;Brown, B. R. ;Cobern, D. ;Roberts, A. ;Somerfield, G. A.


Book ID
121457893
Publisher
The Royal Society of Chemistry
Year
1962
Weight
1014 KB
Category
Article
ISSN
0368-1769

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6-O-Demethylation of the Thevinols with
✍ Simonβ€…W. Breeden; Andrew Coop; Stephenβ€…M. Husbands; Johnβ€…W. Lewis πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 German βš– 59 KB πŸ‘ 2 views

In the pursuit of ring-constrained analogues of buprenorphine, we wished to prepare 6-O-demethylated analogues of the thevinols and orvinols. Previously it had been disclosed that lithium aluminum hydride (LAH) in THF containing a chlorinated solvent could achieve this transformation. Here we report