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311. - Cytochrome P450-26 (CYP2D6) genotype: Relationship with clozapine and haloperidol metabolism

✍ Scribed by J. de Leon; P. Wedlund; R. Ehlers; R. Josianssen; T. Cooper; G. Simpson


Book ID
118858395
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
144 KB
Volume
39
Category
Article
ISSN
0006-3223

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## Abstract The polymorphic enzyme cytochrome P450 CYP2D6 is involved in the metabolism of many antidepressants, including nortriptyline and fluoxetine. Some 7%–10% Caucasians have inactivating mutations in both alleles of the __CYP2D6__ gene, and are referred to as poor metabolizers (PMs). Several