## Abstract ## Background: Deletions and duplications of single exons or exon groups account for a large proportion of the __PARK2__ gene mutations described in juvenile autosomal recessive Parkinson's disease (PD). ## Methods: We analyzed rearrangements in exons 1 to 12 of the __PARK2__ gene in
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3.025 ANALYSIS OF EXON REARRANGEMENTS IN PARK2, SNCA AND PINK1 GENES IN PATIENTS WITH PARKINSON'S DISEASE FROM RUSSIA
β Scribed by E. Semenova; M. Shadrina; P. Slominsky; E. Fedotova; G. Bagyeva; S. Illarioshkin
- Book ID
- 117987865
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 56 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1353-8020
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To date, molecular genetic analyses have identified over 500 distinct DNA variants in five disease genes associated with familial Parkinson disease; Ξ±-__synuclein__ (__SNCA__), __parkin__ (__PARK2__), __PTEN-induced putative kinase 1__ (__PINK1__), __DJ-1__ (__PARK7__), and __Leucine-rich repeat kin
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