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3′-β-ethynyl and 2′-deoxy-3′-β-ethynyl adenosines: first 3′-β-branched-adenosines substrates of adenosine deaminase

✍ Scribed by Denis Tritsch; Pierre M.J. Jung; Alain Burger; Jean-François Biellmann

Book ID
104364924
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
122 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis

AbstractÐThe 3 H -C-branched-adenosine and 2 H -deoxyadenosine analogues 1±7 were tested as substrate of adenosine deaminase. The 9-(3 H -C-ethynyl-b-d-ribo-pentofuranosyl)adenine 1 and its 2 H -deoxy analogue 7 were deaminated by the enzyme while the vinyl and ethyl derivatives 2 and 3 were not. The 9-(3 H -C-branched-b-d-xylo-pentofuranosyl)adenines 4±6 were deaminated by the deaminase.

📜 SIMILAR VOLUMES

ChemInform Abstract: 3′-β-Ethynyl and 2′
ChemInform Abstract: 3′-β-Ethynyl and 2′-Deoxy-3′-β-ethynyl Adenosines: First 3′-β-Branched-Adenosines Substrates of Adenosine Deaminase.
✍ Denis Tritsch; Pierre M. J. Jung; Alain Burger; Jean-Francois Biellmann 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

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