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3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease

โœ Scribed by Thompson, Wayne J.; Ghosh, Arun K.; Holloway, M. Katharine; Lee, Hee Yoon; Munson, Peter M.; Schwering, John E.; Wai, Jenny; Darke, Paul L.; Zugay, Joan


Book ID
126249787
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
423 KB
Volume
115
Category
Article
ISSN
0002-7863

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Structure-based design of achiral, nonpe
โœ Ramnarayan S. Randad; Lucyna Lubkowska; Abelardo M. Silva; Diego M.A. Guerin; Se ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 737 KB

A combination of structure-activity studies, kinetic analysis, X-ray crystallographic analysis, and modeling were employed in the design of a novel series of HIV-1 protease (HIV PR) inhibitors. The crystal structure of a complex of HIV PR with SRSS-2,5-bis[N-(tert-butyloxycarbonyl)amino]-3,4-dihydro