✦ LIBER ✦

(3 R ,4 S )-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: A Conformationally Restricted Analogue of the NR2B Subtype-Selective NMDA Antagonist (1 S ,2 S )-1-(4-Hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidino)-1-propanol

✍ Scribed by Butler, Todd W.; Blake, James F.; Bordner, Jon; Butler, Paul; Chenard, Bertrand L.; Collins, Mary A.; DeCosta, Debra; Ducat, Mary J.; Eisenhard, Michael E.; Menniti, Frank S.; Pagnozzi, Martin J.; Sands, Steven B.; Segelstein, Barbara E.; Volberg, Walter; White, W. Frost; Zhao, Dayao

Book ID: 127100419
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 263 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9707986

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: (3R,4S)-3-[4-(4-Flu

ChemInform Abstract: (3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: A Conformationally Restricted Analogue of the NR2B Subtype-Selective NMDA Antagonist (1S,2S)-1-(4-Hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidino)-1-propanol.

✍ B. L. CHENARD; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Structure of the 2R,3R/2S,3S diastereois

Structure of the 2R,3R/2S,3S diastereoisomer of 1-(2-fluorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-3-pentanol

✍ Branch, S. K. ;Nowell, I. W. 📂 Article 📅 1986 🏛 International Union of Crystallography 🌐 English ⚖ 311 KB

ChemInform Abstract: Discovery of (R)-1-

ChemInform Abstract: Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl] -4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist.

✍ Emmanuel Pinard; Alexander Alanine; Anne Bourson; Bernd Buettelmann; Ramanjit Gi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

Synthesis of N- Substituted 4-(4-Hydroxy

Synthesis of N- Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines: Selective Antagonists at the 1 a /2B NMDA Receptor Subtype

✍ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ω-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent

Preparation of carbon-14 labeled (3R)-7-

Preparation of carbon-14 labeled (3R)-7-hydroxy-N-(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic)

✍ Bertold D. Berrang; Anita H. Lewin; F. Ivy Carroll 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB 👁 1 views

## Abstract Starting with [^14^C]‐D‐tyrosine, carbon‐14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3__R__)‐ and (3__S__)‐diastereomers was carried out via the 3‐phenyl‐2,3,10,10a‐tetrahydro‐5H‐imidazo[1,5‐b]isoquinolin‐

Preparation of carbon-14-labeled (3R)-7-

Preparation of carbon-14-labeled (3R)-7-hydroxy-N-(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic)

✍ Bertold D. Berrang; Anita H. Lewin; F. Ivy Carroll 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB 👁 1 views