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3'-Phosphatase activity in T4 polynucleotide kinase

✍ Scribed by Cameron, Vicki; Uhlenbeck, Olke C.

Book ID: 126009487
Publisher: American Chemical Society
Year: 1977
Tongue: English
Weight: 846 KB
Volume: 16
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi00642a027

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Mammalian polynucleotide kinases (PNKs) carry out 5Ј-phosphorylation of nucleic acids. Although the cellular function(s) of these enzymes remain to be delineated, important suggestions have included a role in DNA repair and, more recently, in DNA replication. Like T4 PNK, some preparations of mammal