3-O-Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells

3-O-methylfunicone produced by penicilli

3-O-methylfunicone produced by penicillium pinophilum affects cell motility of breast cancer cells, downregulating αvβ5 integrin and inhibiting metalloproteinase-9 secretion

✍ Elisabetta Buommino; Mariarosaria Boccellino; Anna De Filippis; Marcella Petrazz 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB

## Abstract Recent evidence assigns integrins and metalloproteinases (MMPs) an important role in regulating tumor cell progression. Here, we demonstrate that 3‐__O__‐methylfunicone (OMF), a secondary metabolite produced by __Penicillium pinophilum__, affects cell proliferation and motility of breas