3-O-Methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated l-DOPA administration in 6-OHDA lesioned rats

Chronic L-DOPA administration is not tox

Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl3 nigrostriatal lesions

✍ Krishna P. Datla; Stavia B. Blunt; David T. Dexter 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 288 KB

## Abstract In this study, we have examined the effects of chronic L‐3,4‐dihydroxyphenylalanine (L‐DOPA) administration on the remaining dopaminergic neurons in rats with 6‐hydroxydopamine (6‐OHDA) or buffered FeCl~3~ partial lesions to the nigrostriatal tract. L‐DOPA administration increased the t