𝔖 Bobbio Scriptorium
✦   LIBER   ✦

3-(N,N-Diacylamino)quinazolin-4(3H)-ones as enantioselective acylating agents for amines

✍ Scribed by Abdullah G Al-Sehemi; Robert S Atkinson; John Fawcett; David R Russell

Book ID
104210031
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
106 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The presence of an N-N chiral axis in a 3-(N-benzoyl-N-isobutanoyl)aminoquinazolin-4(3H)-one (DAQ) bearing a chiral substituent in the 2-position of the quinazolinone allows separation of two enantiopure diastereoisomers; one of these diastereoisomers reacts with racemic 2-methylpiperidine to give (R)(+)-1-benzoyl-2-methylpiperidine (95% ee) and (S)-2-methylpiperidine (91% ee) even using stoichiometric quantities of reagents (1 equiv. DAQ: 2 equiv. amine).

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: 3-(N,N-Diacylamino)
ChemInform Abstract: 3-(N,N-Diacylamino)quinazolin-4(3H)-ones as Enantioselective Acylating Agents for Amines.
✍ Abdullah G. Al-Sehemi; Robert S. Atkinson; John Fawcett; David R. Russell πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v