✦ LIBER ✦

3-methyladenine DNA glycosylases: structure, function, and biological importance

✍ Scribed by Michael D. Wyatt; James M. Allan; Albert Y. Lau; Tom E. Ellenberger; Leona D. Samson

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 121 KB
Volume: 21
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199908)21:8<668::aid-bies6>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

The genome continuously suffers damage due to its reactivity with chemical and physical agents. Finding such damage in genomes (that can be several million to several billion nucleotide base pairs in size) is a seemingly daunting task. 3-Methyladenine DNA glycosylases can initiate the base excision repair (BER) of an extraordinarily wide range of substrate bases. The advantage of such broad substrate recognition is that these enzymes provide resistance to a wide variety of DNA damaging agents; however, under certain circumstances, the eclectic nature of these enzymes can confer some biological disadvantages. Solving the X-ray crystal structures of two 3-methyladenine DNA glycosylases, and creating cells and animals altered for this activity, contributes to our understanding of their enzyme mechanism and how such enzymes influence the biological response of organisms to several different types of DNA damage.

📜 SIMILAR VOLUMES

SH3 domains and drug design: Ligands, st

SH3 domains and drug design: Ligands, structure, and biological function

✍ D. C. Dalgarno; M. C. Botfield; R. J. Rickles 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 567 KB

The ligand binding preferences, structural features, and biological function of SH3 (Src homology 3) domains are discussed. SH3 domains bind ''core'' Pro-rich peptide ligands (7-9 amino acids in length) in a polyproline II helical conformation in a highly conserved aromatic rich patch on the protein

Structure-function analysis of a lupus a

Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA

✍ Zongdong Li; Edward W. Schettino; Eduardo A. Padlan; Hideyuki Ikematsu; Paolo Ca 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB 👁 2 views

To determine the contribution of the somatic point mutations and that of the complementarity-determining region (CDR)3 Arg to DNA binding, we engineered the germline V H and V ‹ gene revertant and site-mutagenized the CDR3 Arg residues of the mutated and "antigen-selected" mAb 412.67. This anti-DNA

ChemInform Abstract: Synthesis, Crystal

ChemInform Abstract: Synthesis, Crystal Structure Determination, and Biological Properties of the DNA-Dependent Protein Kinase (DNA-PK) Inhibitor 3-Cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

✍ Martin Stockley; William Clegg; Gabriele Fontana; Bernard T. Golding; Niall Mart 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis and characterization of biolog

Synthesis and characterization of biologically active new Schiff bases containing 3-functionalized 1,2,4-triazoles and their zinc(II) complexes: crystal structure of 4-bromo-2-[(E)-(1H-1,2,4-triazol-3-ylimino)- methyl]phenol

✍ Zahid H. Chohan; M. Hanif 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB 👁 2 views