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3-hydroxy-3-methylglutaryl–coenzyme a reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats

✍ Scribed by Guido J.E.J. Hooiveld*; ‡; Thera A. Vos‡; George L. Scheffer§; Harry van Goor∥; Hans Koning‡; Vincent Bloks¶; Annemarieke E. Loot*; ‡; Dirk K.F. Meijer*; Peter L.M. Jansen‡; Folkert Kuipers¶; Michael Müller‡

Book ID: 118522055
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 492 KB
Volume: 117
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(99)70462-2

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## Abstract ## Objective Statins, which are used as cholesterol‐lowering agents, have pleiotropic immunomodulatory properties. Although beneficial effects of statins have been reported in autoimmune diseases, the mechanisms of these immunomodulatory effects are still poorly understood. Type I inte