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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell differentiation in cultured adipogenic cells (3T3-L1)

✍ Scribed by Eisuke Nishio; Koji Tomiyama; Hiroko Nakata; Yasuhiro Watanabe


Book ID
115890968
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
354 KB
Volume
301
Category
Article
ISSN
0014-2999

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## Abstract Elevated 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase expression supports synthesis of prenyl pyrophosphate intermediates required for tumor growth. In this study, the copy number of HMG‐CoA reductase mRNA was determined in solid tumor and leukemic cell lines using competit