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3. Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania

✍ Scribed by Hamza A. Babiker; Lisa C. Ranford-Cartwright; David Walliker

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 694 KB
Volume: 93
Category: Article
ISSN: 0035-9203
DOI: 10.1016/s0035-9203(99)90321-8

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✦ Synopsis

Plasmodium falciparum

parasites exist as genetically distinct haploid clones in infected people. In the Kilombero vallev in south-east Tanzania, at least 85% of the inhabitants of Michenga villane harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 l?faZciparum clones at any one time, with a mean of 3.5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0.33.

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