3. Direct action of interleukin-1 elicits distinct effects from microglia, astrocytes, and brain endothelial cells

Interleukin-6 induces transcriptional ac

Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1

✍ Sébastien Loeffler; Bérengère Fayard; Joachim Weis; Jakob Weissenberger 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 780 KB

## Abstract Interleukin‐6 (IL‐6) expression is strongly correlated with the degree of human glioma malignancy and necessary for tumor formation in a mouse model of spontaneous astrocytomas. Yet, exactly how IL‐6 contributes to malignant progression of these brain tumors is still unclear. We have sc