3′-Deoxyribopyranose (4′→2′)-Oligonucleotide Duplexes (=p-DNA Duplexes) as Substitutes of RNA Hairpin Structures

Oligonucleotides Containing Pyrazolo[3,4

Oligonucleotides Containing Pyrazolo[3,4-d]pyrimidines: The Influence of 7-Substituted 8-Aza-7-deaza-2′-deoxyguanosines on the Duplex Structure and Stability

✍ Frank Seela; Georg Becher 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 German ⚖ 186 KB

Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting